Therapeutic Activity of Lenalidomide in Mantle Cell Lymphoma and Indolent Non-Hodgkin’s Lymphomas
نویسندگان
چکیده
منابع مشابه
Therapeutic Activity of Lenalidomide in Mantle Cell Lymphoma and Indolent Non-Hodgkin's Lymphomas
Mantle cell lymphoma (MCL) comprises 3-10% of NHL, with survival times ranging from 3 and 5 years. Indolent lymphomas represent approximately 30% of all NHLs with patient survival largely dependent on validated prognostic scores. High response rates are typically achieved in these patients with current first-line chemoimmunotherapy. However, most patients will eventually relapse and become chem...
متن کاملIndolent mantle cell lymphoma.
Effect of graft source on unrelated donor haemopoietic stem-cell trans-plantation in adults with acute leukaemia: a retrospective analysis. al. Unrelated transplantation for poor-prognosis adult acute lym-phoblastic leukemia: long-term outcome analysis and study of the impact of hematopoietic graft source. R, et al. Favorable outcome of unrelated cord blood transplantation for Philadelphia chro...
متن کاملCombination of Lenalidomide and Rituximab Overcomes Rituximab Resistance in Patients with Indolent B-cell and Mantle Cell Lymphomas.
PURPOSE Lenalidomide, an immunomodulatory agent that enhances antibody-dependent cell-mediated cytotoxicity, has the potential to synergize with rituximab, an anti-CD20 mAb. We hypothesized that the addition of lenalidomide to rituximab would improve clinical outcomes in patients with B-cell lymphomas who were previously rituximab resistant, defined as no response to or progression of lymphoma ...
متن کاملBax mutations are an infrequent event in indolent lymphomas and in mantle cell lymphoma.
BACKGROUND AND OBJECTIVES The Bax gene is one of the most important genes involved in apoptosis regulation. Recently, it has been proposed that inactivating mutations of this death agonist may contribute to the pathogenesis of human tumors. This study was aimed at defining the status of the Bax gene in indolent lymphomas. DESIGN AND METHODS Fifty paraffin-embedded biopsies from indolent lymph...
متن کاملIndolent B-cell non-Hodgkin's lymphomas.
The indolent B-cell non-Hodgkin's lymphomas are a diverse group of disorders that differ markedly with respect to presenting features and natural history. This article reviews entities that have generally been encompassed under the category of indolent lymphomas in various classifications, including the Working Formulation, although many were not specifically identified or labeled as separate e...
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ژورنال
عنوان ژورنال: Advances in Hematology
سال: 2012
ISSN: 1687-9104,1687-9112
DOI: 10.1155/2012/523842